What's the Problem?
Proteins are essential mediators in biological processes. Understanding how and why they interact with each other and with other molecules is crucial to reveal their action mechanism, because, once understood, it can be taken advantage of. Examples include drugs inhibiting certain proteins that cause diseases, empowering enzyme catalytic function to improve reaction yields, or virus nucleocapsid structural analysis for drug-delivery purposes. Unfortunately, even with state-of-the-art modeling techniques, it is impossible to determine a protein’s structural function and interactions based primarily on the amino acid sequence.